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695 areas for the initiation of elimination programs. Initial mapping of areas of high endemicity could be based on surveys conducted by local field teams using pictorial guides of clinical manifestations of yaws. Progress toward the elimination of transmission could be monitored by means of point-of-care serologic surveys for latent yaws in children.4 Finally, as with mass drugadministration programs for controlling and eliminating other infectious diseases, maintaining high levels of community participation in treatment and monitoring will be essential. Azithromycin uptake by 80% or more of eligible community participants, as Mitjà et al. report in Papua New Guinea, with continued targeted community treatment will be critical if local elimination and, ultimately, global eradication of yaws are finally to be realized.